Coevolved-TF-DNA is the database of human and mouse transcription factors, incorporated high-throughput experimental data with co-evolutionary modeling to uncover the TF-DNA binding profiles. Coevolved-TF-DNA includes tools for scanning DNA sequences for potential TF binding sites, as well as predicting the putative genomic binding sites.
Scan sequences for TF binding
For the DNA sequences you are interested, the co-evolutionary can help predict the where are the potential TF binding sites in the given sequences.
Genomic binding target
The co-evolutionary model was further applied to quantify the binding affinity for each position in the human and mouse genome sequence. Putative genomic binding sites with the most favorable scores were reported.
